Sherington is situated in the pleasant countryside of North Buckinghamshire, next to the River Great Ouse, yet is only 7 miles from the centre of the New City of Milton Keynes to which it is linked by good dual carriageway roads.
Newport Pagnell (famous for Aston Martin Lagonda cars and the motorway service station) is 2 miles SW, whilst Olney (famous for its Pancake Race on Shrove Tuesday and where William Cowper lived) is 3 miles N.
The village is 3 miles NE of Junction 14 of the M1 motorway, approximately 50 miles north of London.
Bedford is 13 miles to the east along the A422.
The neighbouring villages are Lathbury, Tyringham, Filgrave, Emberton and Chicheley.